the effect of cationic charge density change on transfection efficiency of polyethylenimine

نویسندگان

zohreh rezvani amin department of chemistry, school of sciences, ferdowsi university of mashhad, mashhad, iran

mohammad rahimizadeh department of chemistry, school of sciences, ferdowsi university of mashhad, mashhad, iran

hossein eshghi department of chemistry, school of sciences, ferdowsi university of mashhad, mashhad, iran

ali dehshahri department of pharmaceutical biotechnology and pharmaceutical sciences research centre, faculty of pharmacy, shiraz university of medical sciences, shiraz, iran

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منابع مشابه

The Effect of Cationic Charge Density Change on Transfection Efficiency of Polyethylenimine

OBJECTIVE(S) Polyethylenimine (PEI) is a potent non-viral gene delivery carrier. PEI surface charge plays a major role in its condensation ability which in turn is a necessary requirement for high transfection efficiency. As the PEI charge density is dependent on pH, the effect of pH changing PEI on PEI condensation ability, transfection efficiency, and cytotoxicity was investigated. MATERIAL...

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The Effect of Linear PEI on Characteristics and Transfection Efficiency of PEI-Based Cationic Nanoliposomes

The development of efficient and safe carrier system to transfer DNA into cells is essential in non-viral gene therapy. The aim of the present study was to evaluate the effect of linear polyetheneimine (lPEI) (2500 Da) on the physicochemical and biological properties of lipopolyplexes constructed from liposomes and lPEI. Materials and Methods Different lipopolymers were synthesized from lPEI ...

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عنوان ژورنال:
iranian journal of basic medical sciences

جلد ۱۶، شماره ۲، صفحات ۱۵۰-۱۵۶

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